In recent years, the management of many diseases of the biliary tract and pancreas has undergone great changes due to the rapid progression of diagnostic and therapeutic technologies. For biliary diseases, the constant technological evolution of endoscopic methods such as EUS, ERCP, and cholangioscopy has changed the diagnostic and therapeutic approach and management of many common pathologies, such as biliary lithiasis and its complications. -Pancreatology is also constantly evolving, both from a clinical and diagnostic–instrumental point of view, such as in the approach to solid and cystic lesions of the pancreas, due to the increasingly routine use of EUS, both diagnostic and therapeutic, and the new knowledge regarding rarer neoplasms such as neuroendocrine tumors. Beyond that, new technologies based on artificial intelligence are beginning to make their way into gastroenterology. The evaluation of patients with biliopancreatic pathology is becoming increasingly complex and challenging. -This reprint presents the latest innovations in the management of pancreatic and biliary tract diseases with the goal of providing the Internal Medicine physician with a state-of-the-art update and insights into the most current innovations.