By Rudy J. Castellani

Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.

Detailed discussion and analysis of early Alzheimer’s disease investigators and their findingsDetailed discussion and analysis of the often-overlooked literature from the 1920’s to the 1960’sDetailed discussion and analysis of aging-related phenomena currently under studyDetailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathyDetailed discussion and analysis of the pathology of autosomal dominant Alzheimer’s disease and Alzheimer’s disease associated with Down syndromePractical issues with diagnosing and reporting Alzheimer’s disease and aging-related changes