Original release date:July 28, 2025

Course Description

This course will provide a comprehensive review and update of the pathologic diagnosis and clinical significance of benign, in situ and malignant lesions of the breast identified in surgical specimens and core needle biopsies. The most current adjunctive immunohistochemical and molecular studies to assist in the diagnosis and classification of benign and malignant breast lesions and to guide patient management will be emphasized.

Target Audience

Practicing academic and community pathologists, and pathologists-in-training

Learning Objectives

Upon completion of this educational activity, learners will be able to:

Describe the diagnostic criteria and clinical significance of a variety of benign, in situ and malignant breast lesions encountered in surgical specimens and core needle biopsies

Discuss differential diagnostic problems in breast pathology and the uses and limitations of ancillary immunohistochemical and molecular tests in arriving at the correct diagnosis

Discuss prognostic and predictive assays in patients with breast cancer

Continuing Medical Education

The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The United States and Canadian Academy of Pathology designates this enduring material for a maximum of 19 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

USCAP is approved by the American Board of Pathology (ABPath) to offer Lifelong Learning credits for the purpose of meeting the ABPath requirements for Continuing Certification (CC).

Contents

Intraductal Proliferative Lesions - Ashley Cimino-Mathews, MD

Update on Classification and Management of LCIS - Stuart Schnitt, MD

Contemporary Issues in Breast Core Needle Biopsies - Laura Collins, MD

Digital Slides: Small Glandular Proliferations - Laura Collins, MD

Digital Slides: Atypical Intraductal Proliferations - Cecily Quinn, MD, FRCPath

Inflammatory and Reactive Lesions - Cecily Quinn, MD, FRCPath

Papillary Proliferations - Edi Brogi, MD, PhD

Challenging Fibroepithelial Lesions - Puay Hoon Tan, MD

Apocrine Proliferations - Cecily Quinn, MD, FRCPath

Digital Slides: Fibroepithelial lesions - Puay Hoon Tan, MD

Spindle Cell Lesions - Cecily Quinn, MD, FRCPath

Vascular Lesions - Gregory Bean, MD, PhD

Applications of Molecular Testing in Breast Cancer - Ashley Cimino-Mathews, MD

Classic Triple Negative Breast Cancers, TILS and the Immune Microenvironment - Ashley Cimino-Mathews, MD

Special Type Triple Negative Breast Cancers - Laura Collins, MD

HER2 Low and ER Low Breast Cancers - Stuart Schnitt, MD

Pathologic Evaluation of Specimens After Neoadjuvant Therapy - Gregory Bean, MD, PhD

Digital Slides: Spindle Cell and Vascular Lesions - Gregory Bean, MD, PhD

Digital Slides: Triple Negative Breast Neoplasms - Stuart Schnitt, MD

Mucinous and Neuroendocrine Lesions - Puay Hoon Tan, MD

Specimen Handling and Margin Evaluation - Laura Collins, MD

Epithelial-Myoepithelial Proliferations - Puay Hoon Tan, MD

Uncommon Clinical Scenarios - Edi Brogi, MD, PhD

Digital Slides: Mucinous Lesions and ER+ Breast Cancers - Ashley Cimino-Mathews, MD

Digital Slides: Unusual Breast Lesions - Edi Brogi, MD, PhD

Uncommon Types of Invasive Breast Cancers - Gregory Bean, MD, PhD

Contemporary Lymph Node Evaluation - Edi Brogi, MD, PhD

Applications of AI to Breast Pathology - Stuart Schnitt, MD

FREE SECTION: Panel Discussion and Q&A