This edition, like the previous editions of this successful text, tries to summarize the controversies and discuss the scientific basis for various causes of recurrent pregnancy loss in depth and to clarify the various treatment modalities. Much of the controversy that previously seemed to have been settled in many areas of recurrent pregnancy loss has now returned again, particularly regarding the use of progestogens, PGT-A, F filgrastim, and anticoagulants, giving this new edition new relevance. Also included here are the continuing advances in genetics and immunomodulation; and the text includes discussion of the roles of evidence-based medicine and personalized medicine and the treatment of the resistant patient. Both general gynaecologists and specialists in recurrent pregnancy loss will find this a helpful reference for their approach to patients. FROM REVIEWS OF PREVIOUS EDITIONS "a leading team … successfully reviews the controversies surrounding each topic… Essential reading for any physician counseling or treating women with recurrent pregnancy loss" ( European Gynecology & Obstetrics) “needed, logically organized, and balanced… a welcome reference ” (Fertility & Sterility)